In anime poison isn’t the most popular form of offensive power. Unlike, fire, ice, or lightning, poison is more subtle. Generally poison is hidden. Often used to casually poison a opponent. Regardless it’s an effect way to incapacitate or even kill an opponent. Here’s the Top 5 Most powerful Shonen Anime Poison Users:

Gordan Agrippa (Black Clover)

Gordon Agrippa is a 1st Class Junior Magic Knight of the Clover Kingdom’s Black Bull squad. Gordon received a poison based Grimoire. He’s able to use poison magic, curse magic, and reinforcement magic. Poison magic is a magic attribute that grants its user the ability to generate and manipulate poison. The poison can take the form of gas or liquid, and in it’s liquid form it can reflect light.

Strongest Attack: Verbotenes Obst

Source: Black Clover Wiki

Sasori of the Red Sand (Naruto)

Sasori is the S-ranked missing-nin from Sunagakure and a member of the Akatsuki. Like most shinobi from the Naruto series he has a variety of abilities. His main from of combat is the use of puppets. Trained by his grandmother, Sasori has a unique ability to create puppets from formerly living beings. When he does this to powerful shinobi he can keep their unique abilities as well. While Sasori never uses poison jutsu directly he coated the many weapons his puppets used with it. Furthermore, he made frequent use of poison gas and deliberately set traps to expose his opponents to it.

Strongest Attack: Third Kazekage (Puppet)

Source: Naruto Wiki

Shinobu Kochou (Demon Slayer)

Shinobu Kochou is the Demon Slayer Corps Insect Hashira. She joined the Corps after demons killed her parents. Like most Hashira, Shinobu is a powerful swordswoman. She lacks the physical strength to decapitate demons so needed to develop another method. Demons are poisoned by Wisteria flowers so Shinobu used her knowledge of medicine and pharmaceutical to create poisons and venoms.

Strongest Attack: Dance of the Centipede: Hundred-Legged Zigzag

Source: Demon Slayer Wiki

Mayuri Kurotsuchi (Bleach)

Mayuri Kurotsuchi is the Captain of the 12th Division in the Gotei 13. Kurotsuchi is a researcher and brilliant scientist. He is sadistic, cruel, and has little regard for the boundaries of other. Mayuri isn’t obsessed with fighting like Kenpachi, but when he engages in battle he’s usually uses mind games. He manually alters his Zanpakuto, Ashisogi Jizo, which can secrete poisonous vapor. The weapon has qualities like a spider bite. When stabbed by Ashisogi Jizo, the combatant’s brain signals shut down. Mayuri’s Bankai, Konjiki Ashisogi Jizo, is a grotesque creature with a baby’s head and caterpillar body. It has the special ability to breathe poison that’s lethal to anyone.

Strongest Attack: Bankai Special Ability

Source: Bleach Wiki

Magellan (One Piece)

Magellan was the chief warden of Impel Down, but was demoted to vice warden after a mass breakout. Magellan ate the Doku Doku no Mi devil fruit. A Paramecia type, the fruit grants Magellan the ability to create and control different kinds of poison. He’s also immune to all forms of poison. Due to its appearance, the ability is often confused with the Logia class. However, Magellan cannot transform into poison. Magellan has control over his poisons strength. He can limit it’s effects to “mild irritant” to “deadly corrosive toxin.”

Magellan can produce his poison in gas or liquid forms. Magellan has the most control of his poison of anyone on this list. He can produce massive amounts of poison, change its shape, and use it as a means of transportation.

Source: One Piece Wiki